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Cannabinoids for glioblastoma: MGC Pharma announces pre-clinical trial results

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Cannabinoids for glioblastoma: MGC Pharma announces pre-clinical trial results
Home » News » Medicinal » Cannabinoids for glioblastoma: MGC Pharma announces pre-clinical trial results

MGC Pharmaceuticals has collaborated with the National Institute of Biology in Slovenia to carry out a three year pre-clinical in vitro research into the use of cannabinoids in the treatment of glioblastoma.

Glioblastoma is a fast-growing and aggressive form of brain tumour, with current treatments consisting of surgery, radiotherapy, chemotherapy and targeted drug therapy. Surviving a Glioblastoma is not common, with only a handful of patients living past two and half years after diagnosis, and less than 5 per cent living beyond five years after diagnosis.

MGC Pharma’s pre-clinical study, undertaken on 30 biopsy samples from 18 patients, sought to determine the optimal formulation for the treatment of the aggressive brain tumour, including the most efficacious ratio of CBD to CBG.

Read more: Phytocannabinoid company MGC Pharma initiates study for long-COVID

The company claims that its proprietary formulations were cytotoxic to glioblastoma tumours and stem cells, reducing the cells’ viability and inducing caspase-dependent cell apoptosis – “cell death”. Glioblastoma stem cells being the main cause of the disease’s progression, and are highly resistant to standard therapies.

It has also stated that tests conducted on the glioblastoma biopsy samples demonstrated that the CBD/CBG treatment’s efficacy was not enhanced by the addition of a widely used chemotherapy treatment, which has been linked to adverse events.

Co-founder and managing director of MGC Pharmaceuticals, Roby Zomer, commented: “The results of this trial are enormously exciting both for the company, and for the treatment of fatal cancerous tumours. 

“MGC Pharma’s research has demonstrated the effect of naturally derived cannabinoid products on stage IV brain tumours without the use of toxic chemotherapy components. 

“We are proud of the work achieved thus far and are looking forward to advancing our proprietary formulation to the next stage of clinical trials.”

MGC Pharma is also undertaking studies in collaboration with UK company, Graft Polymer UK PLC, on the use of a base formulation nano delivery system, based on Graft Polymer’s Graft-Bio IP, to improve the bioavailability of the active compounds using a non-invasive drug administration process, with the study examining the toxicity of the base emulation in order to confirm its safety profile for potential use in its future clinical research.

The company is now planning to undertake additional research to further demonstrate the formulation’s efficacy as a treatment for Glioblastoma.

Medicinal

Khiron announces opening of first Zerenia medical cannabis clinic in Brazil

The new clinic will increase patient access to medical cannabis.

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Khiron announces opening of first Zerenia medical cannabis clinic in Brazil
Home » News » Medicinal » Cannabinoids for glioblastoma: MGC Pharma announces pre-clinical trial results

European medical cannabis group, Khiron, has opened its first Zerenia medical cannabis clinic in Ipanema in Rio de Janeiro, Brazil, as it continues its expansion into the country.

As part of its expansion into a number of jurisdictions across the globe, including Germany and Spain following recent developments, Khiron has now opened its Zerenia Rio clinic.

The clinic will provide physical consultations and telehealth services, connecting patients with medical specialists trained in the ethical, safe and responsible prescription of cannabinoid-based medications.

Read more: Khiron gains German distribution capabilities with new acquisition

The medications focus on the treatment of conditions such as chronic pain, neurological pathologies, palliative care, rheumatology, psychiatry, geriatrics, endocrinology, gastroenterology, gynecology, otorhinolaryngology and dermatology.

Located in Ipanema, a city with more than 12 million people, the clinic’s initial phase will have a total capacity of approximately 23,000 patient consults per year.

The clinic will be under the leadership of Dr Eduardo Faveret as medical director and will open with more than 13 doctors for both in-person and telehealth models.

Read more: Khiron continues expansion into Spain after medical bill green light

Dr Faveret commented: “Brazil continues to experience exponential growth in prescribing doctors and demand for medical cannabis products by patients. Zerenia Rio, is positioned as a comprehensive and humanised pioneer in patient health service and prevention to improve the quality of life of Brazilian families.

“We have assembled a multidisciplinary medical team that covers diverse medical cannabis specialties and treatments, which makes our Zerenia Rio clinic unique in Brazil.”

Dr Faveret and the Zerenia Rio clinic will be supported by Khiron’s strategic alliances with doctors and patient associations, including CANNAB in Salvador de Bahia, and leading medical distributors such as TAIMIN in Rio de Janeiro and Sao Paulo.

Later this year, Khiron is expecting to launch additional THC medical cannabis products in the country, which will complement its current global portfolio.

CEO and director of Khiron Life Sciences, Alvaro Torres, said: “Khiron has developed a unique, successful, and sustainable model with the implementation of Zerenia in Colombia, Perú, and the United Kingdom.

“Brazil is Latin America´s largest addressable market with more than 210 million people and we believe that our Zerenia model will replicate the success we have experienced around the world. 

“We have served more than 25,000 individual patients across the globe through our model, with high peer patient acquisition and retention rates. We have a fantastic team on the ground in Brazil composed of doctors, nurses, patient advocates, and administrative staff in our Zerenia™ Rio clinic that will elevate our patient-first model to new levels. 

“Khiron’s Zerenia Rio clinic in Brazil will also allow us to continue to generate more patient-based evidence on the pharmacoeconomic benefits of our Khiron-branded medical cannabis products, and through this data, Khiron could eventually be able to provide insurance benefits for patients as we have done in Colombia.”

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Akanda and Cansativa to supply German patients with cannabis flower

The collaboration will see patients have access to two novel cultivars.

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Akanda and Cansativa to supply German patients cannabis flower
Home » News » Medicinal » Cannabinoids for glioblastoma: MGC Pharma announces pre-clinical trial results

Akanda Corp and Cansativa are collaborating to supply the German market with dried flowers from Akanda’s EU-GMP certified indoor grow facility in Sintra, Portugal.

Under the collaboration, Akanda is expected to deliver at least 1,000 kg of flower to Cansativa over the first 12 months of the agreement.

All pharmacies in Germany will be able to purchase the products through the Cansativa platform. Since the award of the Federal Institute for Drugs and Medical Devices (BfArM) in August 2020, Cansativa Group is the only company with approval for the distribution of medical cannabis from German cultivation. 

Read more: Akanda to supply cannabis for FDA trials of potential multi-million dollar medicine

Co-founder and CEO of the Cansativa Group, Benedikt Sons, commented: “We are very glad about this agreement that allows us to introduce two novel medical cannabis flowers to the German market. 

“This enables patient access to an additional supplier with a new and innovative range of medical products. This exciting cooperation marks another step in improving the product diversity and security of supply on the German market. 

Read more: Akanda to contest liquidation of its Lesotho-based subsidiary

“We look forward to a long-term relationship with Akanda, with whom we share an important part of our mission: We want to enable physicians, pharmacies, and patients by giving them access to an extensive medical product portfolio and help improve the quality of life with the help of medical cannabis.”

CEO of Akanda, Tej Virk, added: “Our prized purpose-built indoor grow facility is the only one of its kind in Portugal that can produce EU-GMP medical cannabis equivalent to the adult-use grades available in North America. 

“It has both the quality and scalability to meet the growing demand for medical cannabis in fast-growing markets across the EMEA region, such as Germany. 

“We are equally excited to be partnering with the Cansativa Group to bring some of our best strains to Germany through their platform. This supply agreement represents one of the largest agreements in the nascent European medical cannabis industry and is certainly Akanda’s most substantial commercial development to date, enabling new patient experience.”

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Medicinal

Khiron gains German distribution capabilities with new acquisition

Khiron Life Sciences has completed the acquisition of Pharmadrug Production GmbH.

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Khiron gains German distribution capabilities with new acquisition
Home » News » Medicinal » Cannabinoids for glioblastoma: MGC Pharma announces pre-clinical trial results

Through its acquisition of Pharmadrug Production,  Khiron will have access to EU-GMP manufacturing capabilities and a distribution hub for medical cannabis.

Khiron has stated that the acquisition of Pharmadrug Production will provide the company with direct access to German pharmacies and increase in gross margins for its products. 

It will also allow Khiron to accelerate the expansion of its medical product portfolio with additional exclusive flower varieties and a THC‑dominant full spectrum extract that combines the medicinal properties and areas of application of the established THC isolate formulations (dronabinol) with the specific advantages of a full-spectrum extract.

Read more: Khiron continues expansion into Spain after medical bill green light

President of Khiron Europe, Franziska Katterbach, stated: “We are very pleased that we have now received all the necessary permits and licenses in connection with the acquisition and integration of Pharmadrug Production and that we can continue our growth course in Europe on an expedited pace with full control over the value chain up to the pharmacy. We are very excited to take advantage of the Pharmadrug Production’s excellent infrastructure and experienced team, which will enrich us professional and personally. 

“After opening our Zerenia clinic in London last year and now adding a powerful asset in Germany, our European force is complete and ready to ramp our sales in Germany. 

“Now we expect to sell our products faster and at higher margins directly to German pharmacies, which will save distribution fees. A first signal in this direction is the imminent expansion of our medical portfolio for European patients. 

“These are products manufactured exclusively in Europe, and our medical portfolio now covers the entire spectrum of chemotypes and forms of administration. We will provide more detailed information on our new products in a timely manner.”

The development is in line with the Khiron’s strategy to strengthen its foothold in Europe, having also recently welcomed Spain’s progression on the regulation of medical cannabis, stating it is looking forward to bringing its clinical expertise and evidence from Khiron-owned Zerenia Clinics to Spanish patients.

Khiron, which recently reported a record 2022 Q1 with revenue of $4.6m, has stated that additional new products are already in the pipeline, that will comprise the entire spectrum of therapies with medical cannabis to be able to offer the right therapy for every patient.

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